A character can perform a Medicine check to stabilize a dying creature, treat or diagnose a disease or poison, or determine a cause of death. The most commonly used ability score is Wisdom. Examples include the following activities:
| DC | Activity |
| 10 | Assess a broken bone or other obvious injury; stabilize a bleeding creature |
| 15 | Identify the cause of death on a recent corpse; diagnose early signs of a plague |
| 18 | Surgically remove a foreign object in a non-vital area; identify cause of death on an old corpse |
| 20 | Keep a maimed or dismembered creature alive; amputate an infected limb |