Animal Handling allows a character to train or control a domesticated animal, to handle a steed, or to communicate nonaggression to a wild beast. The most commonly used ability score is Wisdom. Examples include the following activities:
| DC | Activity |
| 10 | Calm a warhorse startled in battle; de-escalate aggressive urban wildlife |
| 15 | Calm a riding or draft horse startled by battle; de-escalate territorial wildlife |
| 20 | Earn the immediate trust of urban wildlife; drive a warhorse into extreme peril |
| 22 | Befriend hostile wildlife; drive an untrained mount into battle |